Allergic multimorbidity is associated with self-reported anaphylaxis in adults-A cross-sectional questionnaire study

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Thomander , T , Toppila-Salmi , S , Salimäki , J , Jantunen , J , Huhtala , H , Pallasaho , P & Kauppi , P 2022 , ' Allergic multimorbidity is associated with self-reported anaphylaxis in adults-A cross-sectional questionnaire study ' , Clinical and Translational Allergy , vol. 12 , no. 7 , 12184 . https://doi.org/10.1002/clt2.12184

Title: Allergic multimorbidity is associated with self-reported anaphylaxis in adults-A cross-sectional questionnaire study
Author: Thomander, Tuuli; Toppila-Salmi, Sanna; Salimäki, Johanna; Jantunen, Juha; Huhtala, Heini; Pallasaho, Paula; Kauppi, Paula
Contributor organization: HUS Inflammation Center
Department of Dermatology, Allergology and Venereology
University of Helsinki
Clinicum
HUS Heart and Lung Center
Date: 2022-07
Language: eng
Number of pages: 10
Belongs to series: Clinical and Translational Allergy
ISSN: 2045-7022
DOI: https://doi.org/10.1002/clt2.12184
URI: http://hdl.handle.net/10138/346597
Abstract: Background Anaphylaxis has increased over the last two decades in Europe, reaching an estimated prevalence of 0.3% and an incidence of 1.5-7.9 per 100,000 person-years. Allergic multimorbidity is associated with asthma severity, yet its role in anaphylaxis is not fully understood. Our aim was to study association between allergic multimorbidity and anaphylaxis in adults. Methods We used population-based data from the Finnish Allergy Barometer Study (n = 2070, age range: 5-75). Food allergy (FA), atopic dermatitis (AD), allergic rhinitis (AR) and allergic conjunctivitis (AC), were defined from a self-completed questionnaire. A logistic regression adjusted on potential confounders (sex, age, smoking status) was applied to estimate the anaphylaxis risk associated with allergic multimorbidity. Results 1319 adults with at least one allergic disease (FA, AD, AR, AC) with/without asthma (AS) were included. Of these, 164 had self-reported anaphylaxis [mean (SD, min-max) 54 (14, 22-75) years, 17% men]. AS, FA, AR, AC, or AD were reported by 86.0%, 62.2%, 82.3%, 43.3%, and 53.7% of subjects with anaphylaxis and respectively by 67.8%, 29.5%, 86.2%, 29.4%, and 34.4% of subjects without anaphylaxis. Compared with subjects exhibiting only one allergic disease, the risk of anaphylaxis increased with the number of allergic diseases; adjusted odds ratios (OR) [CI95%] for two, three, four and five coinciding allergic diseases were 1.80 [0.79-4.12], 3.35 [1.47-7.66], 7.50 [3.25-17.32], and 13.5 [5.12-33.09], respectively. The highest risk of anaphylaxis (6.47 [4.33-9.92]) was associated with FA + AS or their various variations with AR/AC/AD embodied, when compared with AR, AC, and AS separately or their combinations. Conclusions Anaphylaxis was positively associated with the number of allergic diseases a subject exhibited and with subgroups including FA and/or AS. The results can be applied when estimating the risk of anaphylaxis for individual patients.
Subject: allergic rhinitis
anaphylaxis
asthma
atopic dermatitis
food allergy
RISK-FACTORS
SEVERITY
ASTHMA
HOSPITALIZATIONS
EPIDEMIOLOGY
POPULATION
INCREASE
RHINITIS
CHILDREN
FINNISH
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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