A rare natural lipid induces neuroglobin expression to prevent amyloid oligomers toxicity and retinal neurodegeneration

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http://hdl.handle.net/10138/346651

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Oamen , H P , Romero , N R , Knuckles , P , Saarikangas , J , Radman-Livaja , M , Dong , Y & Caudron , F 2022 , ' A rare natural lipid induces neuroglobin expression to prevent amyloid oligomers toxicity and retinal neurodegeneration ' , Aging Cell , vol. 21 , no. 7 , 13645 . https://doi.org/10.1111/acel.13645

Title: A rare natural lipid induces neuroglobin expression to prevent amyloid oligomers toxicity and retinal neurodegeneration
Author: Oamen, Henry Patrick; Romero, Nathaly Romero; Knuckles, Philip; Saarikangas, Juha; Radman-Livaja, Marta; Dong, Yuhong; Caudron, Fabrice
Contributor organization: Helsinki Institute of Life Science HiLIFE
Biosciences
Cellular Individuality
Date: 2022-07
Language: eng
Number of pages: 13
Belongs to series: Aging Cell
ISSN: 1474-9718
DOI: https://doi.org/10.1111/acel.13645
URI: http://hdl.handle.net/10138/346651
Abstract: Most neurodegenerative diseases such as Alzheimer's disease are proteinopathies linked to the toxicity of amyloid oligomers. Treatments to delay or cure these diseases are lacking. Using budding yeast, we report that the natural lipid tripentadecanoin induces expression of the nitric oxide oxidoreductase Yhb1 to prevent the formation of protein aggregates during aging and extends replicative lifespan. In mammals, tripentadecanoin induces expression of the Yhb1 orthologue, neuroglobin, to protect neurons against amyloid toxicity. Tripentadecanoin also rescues photoreceptors in a mouse model of retinal degeneration and retinal ganglion cells in a Rhesus monkey model of optic atrophy. Together, we propose that tripentadecanoin affects p-bodies to induce neuroglobin expression and offers a potential treatment for proteinopathies and retinal neurodegeneration.
Subject: amyloid
neurodegeneration
neuroglobin
neuroprotection
protein aggregation
tripentadecanoin
yeast aging
Yhb1
NEURONAL CELL-DEATH
PROTEIN AGGREGATION
NITROSATIVE STRESS
DAMAGED PROTEINS
YEAST
POLYPHOSPHATE
OVEREXPRESSION
ALTERS
GENES
3112 Neurosciences
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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