Hantaviruses and TNF-alpha act synergistically to induce ERK1/2 inactivation in Vero E6 cells.

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Title: Hantaviruses and TNF-alpha act synergistically to induce ERK1/2 inactivation in Vero E6 cells.
Author: Strandin Tomas; Hepojoki Jussi; Wang Hao; Vaheri Antti; Lankinen Hilkka
Contributor: Haartman-instituutti (Kliinisteoreettinen laitos)
Virologian osasto (Kliinisteoreettinen laitos. Haartman-instituutti)
Belongs to series: Virol J
ISSN: 1743-422X
Abstract: BACKGROUND: We have previously reported that the apathogenic Tula hantavirus induces apoptosis in Vero E6 epithelial cells. To assess the molecular mechanisms behind the induced apoptosis we studied the effects of hantavirus infection on cellular signaling pathways which promote cell survival. We previously also observed that the Tula virus-induced cell death process is augmented by external TNF-a ... [More]
URI: 10.1186/1743-422X-5-110
http://hdl.handle.net/10250/3186
Date: 2008-11-14
Rights: green


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