Somatic mutation analysis of MYH11 in breast and prostate cancer.

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Title: Somatic mutation analysis of MYH11 in breast and prostate cancer.
Author: Alhopuro Pia; Karhu Auli; Winqvist Robert; Waltering Kati; Visakorpi Tapio; Aaltonen Lauri A
Contributor: Haartman-instituutti (Kliinisteoreettinen laitos)
Lääketieteellisen genetiikan osasto (Kliinisteoreettinen laitos. Haartman-instituutti)
Belongs to series: BMC Cancer
ISSN: 1471-2407
Abstract: BACKGROUND: MYH11 (also known as SMMHC) encodes the smooth-muscle myosin heavy chain, which has a key role in smooth muscle contraction. Inversion at the MYH11 locus is one of the most frequent chromosomal aberrations found in acute myeloid leukemia. We have previously shown that MYH11 mutations occur in human colorectal cancer, and may also be associated with Peutz-Jeghers syndrome. The mutations ... [More]
URI: 10.1186/1471-2407-8-263
http://hdl.handle.net/10250/3188
Date: 2008-11-14
Subject: Adenocarcinoma
Adult
Aged
Aged, 80 and over
Breast Neoplasms
Cell Line, Tumor
Exons
Female
Humans
Male
Middle Aged
Mutation, Missense
Myosin Heavy Chains
Prostatic Neoplasms
Rights: green


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