Intercellular Adhesion Molecule-5 Induces Dendritic Outgrowth by Homophilic Adhesion

Show full item record



Journal of cell biology. 2000. 150(1): 243-252.

Title: Intercellular Adhesion Molecule-5 Induces Dendritic Outgrowth by Homophilic Adhesion
Author: Tian, Li; Nyman, Henrietta; Kilgannon, Patrick; Yoshihara, Yoshihiro; Mori, Kensaku; Andersson, Leif C.; Kaukinen, Sami; Rauvala, Heikki; Gallatin, W. Michael; Gahmberg, Carl G.
Contributor organization: Biochemistry (Department of Biological and Environmental Sciences)
Biokemia (Bio- ja ympäristötieteiden laitos)
Biokemi (Institutionen för bio- och miljövetenskaper)
Publisher: Rockefeller University Press
Date: 2000
Language: eng
ISSN: 0021-9525
Abstract: Intercellular adhesion molecule-5 (ICAM-5) is a dendritically polarized membrane glycoprotein in telencephalic neurons, which shows heterophilic binding to leukocyte b2-integrins. Here, we show that the human ICAM-5 protein interacts in a homophilic manner through the binding of the immunoglobulin domain 1 to domains 4–5. Surface coated ICAM-5-Fc promoted dendritic outgrowth and arborization of ICAM- 5–expressing hippocampal neurons. During dendritogenesis in developing rat brain, ICAM-5 was in monomer form, whereas in mature neurons it migrated as a high molecular weight complex. The findings indicate that its homophilic binding activity was regulated by nonmonomer/monomer transition. Thus, ICAM-5 displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes.
Subject: leukocyte

Files in this item

Total number of downloads: Loading...

Files Size Format View
243.pdf 476.7Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record